Journals

Journals 12 24 December: Avian Influenza Ebola Middle East Respiratory Syndrome (MERS-CoV) Prevention and Preparedness Antimicrobial Resistance Vaccines and Antivirals Zoonoses and Animal Diseases

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Contents: Avian Influenza Ebola Middle East Respiratory Syndrome (MERS-CoV) Prevention and Preparedness Antimicrobial Resistance Vaccines and Antivirals Zoonoses and Animal Diseases

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ABSTRACT

Zoonotic avian influenza virus infections may lead to epidemics or pandemics. The 1918 pandemic influenza virus has an avian influenza virus-like genome, and its H1 hemagglutinin was identified as a key mammalian virulence factor. A chimeric 1918 virus expressing a contemporary avian H1 hemagglutinin, however, displayed murine pathogenicity indistinguishable from that of the 1918 virus. Here, isogenic chimeric avian influenza viruses were constructed on an avian influenza virus backbone, differing only by hemagglutinin subtype expressed. 

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